INTRODUCTION: Telogen effluvium (TE), the most common cause of diffuse hair shedding, is a non-inflammatory process characterized by the widespread loss of hair follicles at telogen phase. Identification of its etiology requires laboratory tests involving endocrine, nutritional and autoimmune disorders, and detailed anamnesis. The aim of this study was to examine serum ferritin, folate and vitamin B12 levels in female patients with TE, and to investigate their possible role in the disease pathogenesis
METHODS: The study included totally 651 female patients; 455 in the TE group and 196 in the control group. Serum ferritin, folate and vitamin B12 levels were measured in all groups.
RESULTS: Patients with TE had significantly lower serum ferritin concentrations compared to the controls (17.35±18.54 ng/ml vs. 39.27±29.44 ng/ml) (p=0.001). Folate levels were significantly lower in the TE group compared to the control group (7.94±8.98 ng/ml vs. 11.31±4.7 ng/ml) (p=0.001). Vitamin B12 concentrations were also significantly lower in the TE group (232.13±123.35 pg/ml) (p=0.001).
DISCUSSION AND CONCLUSION: We think reduced levels of ferritin, vitamin B12 and folate might play role in development of TE.