ISSN  2587-2362  |  E-ISSN  2618-642X

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International Journal of Medical Biochemistry Bone markers [Int J Med Biochem ]
Int J Med Biochem . Ahead of Print: IJMB-60362 | DOI: 10.14744/ijmb.2019.60362

Bone markers

Dildar Konukoğlu
Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Medical Biochemistry

The bone has a dynamic metabolism with modeling and remodeling activities. There is a continuous communication between bone cells including osteoblast and osteoclast, as well as osteocyte. Local stress factors, cytokines and hormones play an importantroles in these relationships. The most important structural component of bone is type I collagen. During the formation and degradation of collagen, some compounds secrete into the bloodstream and in relation to diseases involving the bone, these compounds increase both in the blood concentration and urinary excretion. In relation to diseases involving the bone, these compounds increase both in the blood concentration and urinary excretion. Some of the bone markers are secreted into the circulation during bone formation, and some of them are released into the circulation by bone resolution. However, bone markers reflect changes in bone metabolism due to primary or secondary causes rather than a specific bone disease. On the other hand, some factors affecting the results should be considered during the evaluation of the changes. These factors include both preanalytical effects such as age, gender, diurnal rhythm, and analytical problemsIn this review, the current applications of bone turnover markers and the effects of preanalytical conditions are summarized.

Keywords: Bone marker, bone cells, bone biochemistry



Corresponding Author: Dildar Konukoğlu, Türkiye
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