INTRODUCTION: Alzheimer’s is a fatal multifactorial neurodegenerative disorder characterized by progressive neuronal loss and loss of cognitive functions and its etiology has not been fully elucidated. In some studies, central nervous system infections have been suggested to play a role in the development of Alzheimer’s disease. The aim of the present study is to investigate the possible relationship between latent infection with Toxoplasma gondii in astrocytes and S100 protein released as a result of astrocyte damage.
METHODS: In this study, 33 patients with AD and 32 healthy individuals were included. In the Alzheimer’s disease group 16 Toxoplasma negative and 17 Toxoplasma positive patients were included in the study whereas in the control group 15 Toxoplasma negative and 17 Toxoplasma positive people were included in the study.
RESULTS: There were no statistically significant differences between the groups in terms of mean age and gender. The inter-group comparison of the subjects revealed that S100B levels were higher in patients with Alzheimer’s disease than those in the control group (p<0.05). There was no statistically significant difference between the groups in terms of T.gondii IgG test (p>0.05).
DISCUSSION AND CONCLUSION: In our study, although there was no relationship between T.gondii infection and Alzheimer’s disease, significantly higher levels of S100B in patients with Alzheimer’s disease suggest that this protein may be important both in diagnosis and in possible treatment processes. The authors suggest that reproduction of the current study using different genotypes of T.gondii would contribute to the etiology of AD, which has yet to be elucidated.