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International Journal of Medical Biochemistry Procalcitonin in the diagnosis of sepsis and its correlations with upcoming novel diagnostic markers [Int J Med Biochem ]
Int J Med Biochem . Ahead of Print: IJMB-30502 | DOI: 10.14744/ijmb.2019.30502

Procalcitonin in the diagnosis of sepsis and its correlations with upcoming novel diagnostic markers

Mustafa Erinç Sitar1, Belkiz Ongen Ipek1, Aslı Karadeniz2
1Maltepe Üniversitesi Tıp Fakültesi Eğitim Araştırma Hastanesi Merkez Laboratuvarı Tıbbi Biyokimya
2Maltepe Üniversitesi Tıp Fakültesi Eğitim Araştırma Hastanesi Merkez Laboratuvarı Enfeksiyon Hastalıkları Ve Klinik Mikrobiyoloji

Sepsis is a complex and lethal condition. For successful treatment, clinicians need high quality testing to guide the pathogen identification and treatment approach. In this regard, the main task of medical laboratories with the detection of infective agent is to reveal new and reliable tests, to experience the reliability of existing tests in different diseases and to expand their usage areas. Selecting appropriate therapy, reducing usage of antibiotics and so declining antibiotic resistance are also undeniable parts of this task. The most commonly used parameters, for directing infection therapy, include measuring white blood cell count, erythrocyte sedimentation rate, absolute count of neutrophils, absolute number of lymphocytes, C reactive protein, serum amyloid A protein, ceruloplasmin, haptoglobin, fibrinogen and finally procalcitonin (ProCT). Although ProCT has been accepted to be quite effective in differentiating serious bacterial infections, there are unsolved questions regarding its effective usage during follow-up periods and with other markers. In this review, ProCT, sepsis and other promising bio-markers were identified as the focus. Starting from the first study, which defined ProCt in the literature, the studies on the importance of ProCT sepsis relation in the modern medicine have been reviewed and detailed information is given on candidate markers.

Keywords: Biomarker, CRP, Procalcitonin, Reference Interval, Sepsis



Corresponding Author: Mustafa Erinç Sitar, Türkiye
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